Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.

Title:

Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.

Dataset

identifier:	1418719
description:	epitope description:YGGPANKKNAG antigen name:Merozoite surface protein 1 host organism:Aotus nancymaae antibody name:Aotus sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	17403557

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005960
landingPage:	http://www.iedb.org/assay/1418719

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2007

Dimension

study type:	b cell assays
subject species:	Plasmodium

Person

fullName:	Adriana Bermú dez Claudia Reyes Fanny Guzmá n Magnolia Vanegas Jaiver Rosas Roberto Amador Raul Rodrí guez Manuel Alfonso Patarroyo Manuel Elkin Patarroyo

Data Type

method:	ELISA

Study

name:	Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.
description:	The epitope residues were derived by sequencing the N-terminal region of 35K fragments of proteins isolated from schizont and merozoite lysates. High antibody titers against the SPf66 chimeric protein and its constituent peptides were achieved following vaccination with the SPf66 vaccine. This epitope was recognized by all immunized animals tested in Leticia, Colombia. However, a totally different response were observed in a trial carried out at the CDC in Atlanta where sera from SPf66-immunized monkeys (5/5) exclusively recognized the 35.1 epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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