Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.

Title:

Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.

Dataset

identifier:	1418723
description:	epitope description:YGGPANKKNAG antigen name:Merozoite surface protein 1 host organism:Aotus nancymaae antibody name:Aotus sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	17403557

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005960
landingPage:	http://www.iedb.org/assay/1418723

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2007

Dimension

study type:	b cell assays
subject species:	Plasmodium

Person

fullName:	Adriana Bermú dez Claudia Reyes Fanny Guzmá n Magnolia Vanegas Jaiver Rosas Roberto Amador Raul Rodrí guez Manuel Alfonso Patarroyo Manuel Elkin Patarroyo

Data Type

method:	western blot

Study

name:	Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.
description:	The epitope residues were derived by sequencing the N-terminal region of 35K fragments of proteins isolated from schizont and merozoite lysates. Sera from monkeys immunized with the chimeric SPf66 vaccine reacted with solubilized P. falciparum schizont antigens in western blot analysis. The reactivity with the cleavage products shown on the gel were consistent with the fragments from which the epitope was derived. The use of QS-21 as adjuvant with SPf66 instead of Freund's notably increased antibody titers.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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