Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy.

Title:

Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy.

identifier:	1420156
description:	epitope description:KEDVPSERYLGYLEQLLRLK antigen name:Bos d 9 host organism:Homo sapiens antibody name:patient sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	11174208

study type:	b cell assays
subject species:	Bos taurus

fullName:	P Chatchatee K M Jä rvinen L Bardina K Beyer H A Sampson

method:	ELISA

name:	Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy.
description:	Data originally imported from the Database of Functional Molecular Immunology, FIMM (http://sdmc.lit.org.sg:8080/fimm/) and recurated. The following refers to the epitope id as found in the original FIMM database: P001877 The epitope sequence was deduced through study of overlapping decapeptides spanning the sequence of alpha-S1-casein. The epitope was a major IgE binding region based on cumulative densitometric ODs. The epitope was recognized by 67% of patients (> 9 years) with persistent cow's milk allergy (CMA) and by 13% of younger patients (< 3 years), who are likely to outgrow their CMA. The epitope sequence partially overlaps with an IgG binding epitope (residues 93-108).

name:	iedb
homePage:	http://www.iedb.org

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