Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.

Title:

Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.

identifier:	1436246
description:	epitope description:CCRHKQKIVAPVKQTLPPSVPNLRGDLQVLAQKVARTPCG host organism:Bos taurus antibody name:Cattle sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	2157884

study type:	b cell assays
subject species:

fullName:	T R Doel C Gale C M Do Amaral G Mulcahy R Dimarchi

method:	biological activity

name:	Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.
description:	This peptide is comprised of two epitopes (RHKQKIVAPVKQTL , aa 924-937, and VPNLRGDLQVLAQKVART, aa 865-882) derived from the VP1 protein of foot and mouth disease virus strain O₁ Kaufbeuren, Genbank accession no. 130448. The peptides are linked by the amino acid residues PPS and are synthesized with two amino-terminal cysteine residues and a carboxy-terminal PCG. These amino acid numbers do not match those in the paper (200-213 and 141-158 for VP1, respectively) because the full polyprotein is referenced, as opposed to the VP1 protein that is processed from the polyprotein. Significant virus-neutralizing titers against the heterotypic A seroptype were achieved in cattle immunized with peptide O40 with this regimen. In a separate experiment, when a single dose of 1mg of O40 was used, no animals responded.

name:	iedb
homePage:	http://www.iedb.org

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