High-affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease.

Title:

High-affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease.

identifier:	1459804
description:	epitope description:CCRHKQKIVAPVKQTLPPSVPNLRGDLQVLAQKVARTPCG host organism:Bos taurus Friesian antibody name:Cattle sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	1847695

study type:	b cell assays
subject species:

fullName:	M W Steward C M Stanley R Dimarchi G Mulcahy T R Doel

method:	radio immuno assay (RIA)

name:	High-affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease.
description:	This synthetic peptide is comprised of two epitopes (aa 200-213 and 141-158) derived from the VP1 protein of the O₁ Kaufbeuren strain of FMDV joined by a PPS linker and flanked by CC on the amino terminus and PCG on the carboxy terminus. A blast search shows that these sequences correspond to amino acids 924-937 and 865-882, respectively, of GI:130448. Antibody in sera from animals protected from challenge had a higher affinity for peptide than in sera from unprotected animals. This difference was seen at 14 days post-immunization with a peak at 21 days, continuing higher through 25 days.

name:	iedb
homePage:	http://www.iedb.org

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