Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus.

Title:

Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus.

Dataset

identifier:	1460919
description:	epitope description:R429 antigen name:Fusion glycoprotein F0 host organism:Mus musculus BALB/c antibody name:MAbs 19 and 20
aggregation:	instance of dataset
availability:	available
primaryPublications:	1383404

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006421
landingPage:	http://www.iedb.org/assay/1460919

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	1992

Dimension

study type:	b cell assays
subject species:	Human respiratory syncytial virus A strain Long

Person

fullName:	J Arbiza G J A Ló pez J Furze S Wyld P Whyte E J Stott G Wertz W Sullender M et al.

Data Type

method:	biological activity

Study

name:	Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus.
description:	All mutants selected with mAbs 19 and 20 contained a single change of Arg to Ser at residue 429. A linear epitope was further defined for mAb 19, therefore R429 was determined to be a critical residues in binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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