Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1006492 |
| landingPage: |
http://www.iedb.org/assay/1462911 |
| type: |
Literature
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| publicationVenue: |
Vaccine
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Pasteurella multocida X-73 |
| fullName: |
Y Luo
Q Zeng
J R Glisson
M W Jackwood
I H Cheng
C Wang
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| method: |
in vivo assay
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| name: |
Sequence analysis of Pasteurella multocida major outer membrane protein (OmpH) and application of synthetic peptides in vaccination of chickens against homologous strain challenge.
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| description: |
Although Cyclic-L2 induced low antibody titers against both homologous peptide and native protein (whole cell and whole cell lysate), this cyclic form of the epitope protected 70% (7/10) of chickens from lethal challenge with P. multocida (X-73). The authors suggest that the protection was due to the ability of Cyclic-L2 to mimic the predicted loop 2 of the OmpH protein. The cyclization of the peptides was achieved by oxidation of free cysteinyl thiol groups added to the N- and C-terminus of the epitope. The linear epitope (MAP-L2) failed to protect.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
