A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.

Title:

A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.

Dataset

identifier:	1462975
description:	epitope description:NAGYAGGKFKHPFSSFDKEDNEQVSGS antigen name:31 kDa outer-membrane immunogenic protein host organism:Mus musculus BALB/c antibody name:Anti-rBLSOmp31 mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	17442465

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006653
landingPage:	http://www.iedb.org/assay/1462975

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2007

Dimension

study type:	b cell assays
subject species:	Brucella melitensis

Person

fullName:	Juliana Cassataro Karina A Pasquevich Silvia M Estein Diego A Laplagne Carlos A Velikovsky Silvia de la Barrera Raú l Bowden Carlos A Fossati Guillermo H Giambartolomei Fernando A Goldbaum

Data Type

method:	in vivo assay

Study

name:	A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.
description:	This peptide attached to BLS carrier provided better protection against heterotypic rough B. ovis challenge than the Omp 31peptide, Omp31, or BLS alone. The covalently linked Omp31 peptide-BLS was better than the peptide and BLS administered together, or Omp31 and BLS administered together. Covalently linked Omp31 peptide-BLS provided comparable protection to a live attenuated Brucella mellitensis vaccine strain or a hot saline extract of Brucella used as a vaccine.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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