Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.

Title:

Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.

Dataset

identifier:	1161
description:	epitope description:YQPIDVVRDLPSGFNTL antigen name:Spike glycoprotein host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	15356154

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/406
landingPage:	http://www.iedb.org/assay/1161

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	SARS coronavirus Tor2

Person

fullName:	Yuxian He Yusen Zhou Hao Wu Baojun Luo Jingming Chen Wanbo Li Shibo Jiang

Data Type

method:	ELISA

Study

name:	Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.
description:	The epitope sequence was cited in Li et. al. Nature 426 (6965), 450-454 (2003) [PMID:14647384]. Pepscan analysis against antisera from rabbits immunized with inactivated SARS-CoV was performed. Reactivity of the rabbit antisera at 1/100 dilution with peptides overlapping the entire sequence of the S protein was measured by ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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