Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.

Title:

Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.

identifier:	1048
description:	epitope description:DWIWNQMHIDEEKNE antigen name:Cadherin-5 host organism:Rattus norvegicus Lewis antibody name:E4G10
aggregation:	instance of dataset
availability:	available
primaryPublications:	15701713

study type:	b cell assays
subject species:	Mus musculus

fullName:	Chad May Jacqueline F Doody Rashed Abdullah Paul Balderes Xiaohong Xu Chien Peter Chen Zhenping Zhu Lawrence Shapiro Paul Kussie Daniel J Hicklin Fang Liao Peter Bohlen

method:	flow cytometry

name:	Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.
description:	Antibody (E4G10) was elicited by immunizing with mature VE-cadherin aa 1-15 but the epitope was mapped further to aa 1-10. The epitope is recognized by an antibody (E4G10) that inhibits angiogenesis and tumor growth without disrupting normal vessels, which results in vascular leakage. The precursor protein is processed the mature protein's N-terminus starts at aa 46. Identification of the residues of the epitope was performed via mutation (Alanine scan) and truncation analysis.

name:	iedb
homePage:	http://www.iedb.org

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