A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibody.

Title:

A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibody.

identifier:	3576
description:	epitope description:IAVAGDLFQPER antigen name:Growth arrest-specific protein 6 host organism:Mus musculus (CBA/J X C57BL/6J) human IgH Tg human IgL Tg antibody name:CNTO300
aggregation:	instance of dataset
availability:	available
primaryPublications:	15579134

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Paul W Fisher Michael Brigham-Burke Sheng-Jiun Wu Jinquan Luo Jill Carton Kim Staquet Wei Gao Sheila Jackson Deidra Bethea Cailin Chen Bing Hu Jill Giles-Komar Jing Yang

method:	ELISA

name:	A novel site contributing to growth-arrest-specific gene 6 binding to its receptors as revealed by a human monoclonal antibody.
description:	Epitope was determined via binding of a peptide to CNTO300 monoclonal antibody the antibody was raised against Gas6_Flag protein. A synthetic peptide containing the epitope sequence only weakly bound to CNTO300, thus, the epitope is not merely a linear sequence structural features are required for optimal binding to the antibody. Antibody protected protease digestion and mass spectrometry identified the epitope.

name:	iedb
homePage:	http://www.iedb.org

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