Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.

Title:

Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.

Dataset

identifier:	1660
description:	epitope description:EEEKKEEKKEEKKPDNEITNEVKEEQKYSSPSDINAQNLISN antigen name:Merozoite surface protein 6 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15664972

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/297
landingPage:	http://www.iedb.org/assay/1660

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2005

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum 3D7

Person

fullName:	Subhash Singh Soe Soe Christian Roussilhon Giampietro Corradin Pierre Druilhe

Data Type

method:	ELISA

Study

name:	Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.
description:	Sera from malaria-protected subjects recognized the epitope. The majority of the response was characterized by the IgG1 and IgG3 subclasses, but IgG2 and IgG4 were also found to bind, though at lower levels. Antibodies affinity purified using the peptide bound only to the epitope and showed no cross-reactivity to adjacent regions.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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