Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/418 |
| landingPage: |
http://www.iedb.org/assay/5600 |
| type: |
Literature
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| publicationVenue: |
J Biol Chem
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| dates: |
2005
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| study type: | b cell assays |
| subject species: |
| fullName: |
Beihai Jiang
Wenbin Liu
Hong Qu
Lin Meng
Shumei Song
Tao Ouyang
Chengchao Shou
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| method: |
ELISA
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| name: |
A novel peptide isolated from a phage display peptide library with trastuzumab can mimic antigen epitope of HER-2.
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| description: |
A mimotope (H98) for HER-2 protein identified from a peptide library via binding with a specific monoclonal antibody (Trastuzumab). A linear sequence (12-mer) is specified, however, only some of the amino acids (G3, P4, S11, 12H) and a minimum number of residues (8) are critical for antibody binding. There is no linear sequence in HER-2 that corresponds to H98
this is because H98 mimics a conformational epitope rather than a linear epitope.
Binding increased as the number of immunizations increased.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
