Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/603 |
| landingPage: |
http://www.iedb.org/assay/5669 |
| type: |
Literature
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| publicationVenue: |
Virology
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| dates: |
2004
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| study type: | b cell assays |
| subject species: | SARS coronavirus |
| fullName: |
Jian-Ping Guo
Martin Petric
William Campbell
Patrick L McGeer
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| method: |
biological activity
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| name: |
SARS corona virus peptides recognized by antibodies in the sera of convalescent cases.
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| description: |
This sequence is an author-deduced epitope, representing the overlapping region of two adjacent 10-mer peptides.
This epitope was identified in convalescent sera by probing cellulose membrane-bound peptides. Acute sera were collected on presentation, and convalescent sera collected 1 month later in case 1, and at least 2 weeks later in cases 2, 3, and 4. Virus neutralization titers indicated that the four recovered cases developed antibodies with viral neutralizing potency between the time of acute and convalescent serum sampling. Therefore, those peptides strongly recognized on membranes probed with convalescent sera, but not with acute or control sera, should be the most immunodominant and may include SARS-CoV epitopes that are vulnerable to neutralization by antibody. As controls, serum from one case that failed to survive, and one from a healthy, nonexposed volunteer was utilized.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
