Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/654 |
| landingPage: |
http://www.iedb.org/assay/6396 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
2004
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| study type: | b cell assays |
| subject species: | Vibrio cholerae O1 |
| fullName: |
Ronald K Taylor
Thomas J Kirn
Michael D Meeks
Terri K Wade
William F Wade
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| method: |
ELISA
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| name: |
A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure.
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| description: |
Rabbits were universally able to make anti-TcpA polypeptide antibodies and the titers increased with time and booster immunizations. Sera from the preimmune bleed showed low background levels. Antiserum from peptide-immunized rabbits was combined with a known dose of virulent V. cholerae and introduced via gavage into the gut of 4- to 5-day-old infant CD-1 mice, but no protection was conferred.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
