B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein.

Title:

B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein.

Dataset

identifier:	6972
description:	epitope description:QILPDPLKPTKRSFIEDLLFNKVTLA + ACET(Q1) antigen name:Spike glycoprotein host organism:Homo sapiens antibody name:anti-spike S2 Ab (from convalescent plasma)
aggregation:	instance of dataset
availability:	available
primaryPublications:	15731234

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/696
landingPage:	http://www.iedb.org/assay/6972

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2005

Dimension

study type:	b cell assays
subject species:	SARS coronavirus

Person

fullName:	Xiaofen Zhong Huanghao Yang Zu-Feng Guo Wan-Yee Fion Sin Wei Chen Junjie Xu Ling Fu Jie Wu Chun-Kit Gannon Mak Chak-Sum Samuel Cheng Yanzhen Yang Shuyong Cao Tin-Yau Wong Sik-To Lai Yong Xie Zhihong Guo

Data Type

method:	biological activity

Study

name:	B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein.
description:	This sequence is denoted by authors as an epitope-rich region encompassing an identified convergent region for antibody from convlescent sera of SARS-CoV patients who have recovered. The authors identified 5 peptides within this region and these peptidesfell into two distinct groups of peptides corresponding to two putatively distinct distinct epitopes. For experimental purposes the N-terminus of the synthetic peptide was N-acetylated. Protection of SARS-CoV infection of Vero E6 cells was measured by addition of sera from convalescent patient J. Blocking of protection was demonstrated by pre-mixing sera with SL21 epitopic region.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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