Antigenic properties of peptidic mimics for epitopes of the lipopolysaccharide from Brucella. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic properties of peptidic mimics for epitopes of the lipopolysaccharide from Brucella.

Dataset

identifier:	8043
description:	epitope description:GPGQCNTRNPCPRPM host organism:Mus musculus antibody name:A15-6B3
aggregation:	instance of dataset
availability:	available
primaryPublications:	10556037

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/771
landingPage:	http://www.iedb.org/assay/8043

Publication

type:	Literature
publicationVenue:	J Mol Biol
dates:	1999

Dimension

study type:	b cell assays
subject species:

Person

fullName:	X De Bolle T Laurent A F Godfroid V Weynants J J Letesson P Mertens

Data Type

method:	antigen inhibition

Study

name:	Antigenic properties of peptidic mimics for epitopes of the lipopolysaccharide from Brucella.
description:	Possible mimotope of Brucella sp. LPS M epitope. Immunization with the phage particle displaying this peptide is reported to induce weak anti-LPS responses in mice. Peptide selected from phage display library by biopanning against a mAb specific for M epitope of LPS from Brucella. Other mAbs against LPS do not recognize this peptide (Figure 1). This epitope competes with the binding of Ab A15-6B3 to type M LPS. This effect was also seen with the phage particle expressing the epitopic peptide in both an identical and in the reciprocal assay (fig 2).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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