Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus.

Dataset

identifier:	9093
description:	epitope description:NANPNANPNANP antigen name:Circumsporozoite (CS) protein host organism:Mus musculus antibody name:mAb 2A10
aggregation:	instance of dataset
availability:	available
primaryPublications:	11812154

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/842
landingPage:	http://www.iedb.org/assay/9093

Publication

type:	Literature
publicationVenue:	J Mol Biol
dates:	2002

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	Myrna C Bonaldo Richard C Garratt Philippe S Caufour Marcos S Freire Mauricio M Rodrigues Ruth S Nussenzweig Ricardo Galler

Data Type

method:	immuno staining

Study

name:	Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus.
description:	Dominant epitope of CS protein of P. falciparum sporozoites. The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host). It harbors several tandem repeats of the epitopic sequence. Vero cells infected with yellow fever virus expressing P. falciparum epitope are recognized by monoclonal antibody against the epitope. This antibody is also shown to immunoprecipitate E viral protein-epitope chimera from cell lysates.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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