Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/929 |
| landingPage: |
http://www.iedb.org/assay/10634 |
| type: |
Literature
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| publicationVenue: |
J Clin Microbiol
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| dates: |
2000
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| study type: | b cell assays |
| subject species: | Rabies virus Ontario fox |
| fullName: |
S A Nadin-Davis
M Sheen
M Abdel-Malik
L Elmgren
J Armstrong
A I Wandeler
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| method: |
antigen inhibition
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| name: |
A panel of monoclonal antibodies targeting the rabies virus phosphoprotein identifies a highly variable epitope of value for sensitive strain discrimination.
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| description: |
N terminal Cys is not part of the natural epitope sequence. This peptide is shown to reside in antigenic region II of source protein, highly source species specific, with mAbs recognizing this region unable to react with 31 other lyssaviruses assayed.
This peptide was able to compete binding to source protein of mAbs directed to antigenic site II, previously defined to reside in aa 145-165. This of data suggests that the antigenic region is aa 154-168. This region is highly source species specific, with mAbs recognizing this region unable to react with 31 other lyssaviruses assayed.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
