Antigenic epitopes of the hepatitis A virus polyprotein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic epitopes of the hepatitis A virus polyprotein.

Dataset

identifier:	14001
description:	epitope description:SDSVGQQIKVIPVDPYFFQM antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10417261

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/941
landingPage:	http://www.iedb.org/assay/14001

Publication

type:	Literature
publicationVenue:	Virology
dates:	1999

Dimension

study type:	b cell assays
subject species:	Human hepatitis A virus Hu/Australia/HM175/1976

Person

fullName:	Y E Khudyakov E N Lopareva D L Jue S Fang J Spelbring K Krawczynski H S Margolis H A Fields

Data Type

method:	ELISA

Study

name:	Antigenic epitopes of the hepatitis A virus polyprotein.
description:	This peptide is part of an immunoreactive domain (aas308-340 in the viral polyprotein sequence) with weak but significant specific reactivity with acute-phase sera samples. It includes residues D315 and Q319 which had been found previously to be essential residues of the HAV major conformational neutralizing epitope. Swiss-prot ID and positions correspond to the genome polyprotein, not to the mature source protein. 2.4% of acute phase sera recognize this peptide while 0% of normal human sera samples do.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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