Antigenic epitopes of the hepatitis A virus polyprotein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic epitopes of the hepatitis A virus polyprotein.

Dataset

identifier:	14018
description:	epitope description:QNVPDPQVGITTMKDLKGKA antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10417261

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/941
landingPage:	http://www.iedb.org/assay/14018

Publication

type:	Literature
publicationVenue:	Virology
dates:	1999

Dimension

study type:	b cell assays
subject species:	Human hepatitis A virus Hu/Australia/HM175/1976

Person

fullName:	Y E Khudyakov E N Lopareva D L Jue S Fang J Spelbring K Krawczynski H S Margolis H A Fields

Data Type

method:	ELISA

Study

name:	Antigenic epitopes of the hepatitis A virus polyprotein.
description:	This peptide is part of an immunoreactive domain (aas 501-526 in the viral polyprotein sequence) with significant specific reactivity with acute-phase sera samples. Swiss-prot ID and positions correspond to the genome polyprotein, not to the mature source protein. 30.4% of acute phase sera recognize this peptide while 0% of normal human sera samples do. Region 502-516, partially overlapping with this peptide, was shown previously to elicit HAV neutralizing antibodies. Analysis of reactivity of seroconversion panels from humans or chimpanzees (not shown) reveals that the reactivity seen is short lasting, correlating with an acute phase indicator (ALT levels).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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