Antigenic epitopes of the hepatitis A virus polyprotein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic epitopes of the hepatitis A virus polyprotein.

Dataset

identifier:	14035
description:	epitope description:TPVGLAVDTPWVEKESALSI antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10417261

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/941
landingPage:	http://www.iedb.org/assay/14035

Publication

type:	Literature
publicationVenue:	Virology
dates:	1999

Dimension

study type:	b cell assays
subject species:	Human hepatitis A virus Hu/Australia/HM175/1976

Person

fullName:	Y E Khudyakov E N Lopareva D L Jue S Fang J Spelbring K Krawczynski H S Margolis H A Fields

Data Type

method:	ELISA

Study

name:	Antigenic epitopes of the hepatitis A virus polyprotein.
description:	Residues V171 and A176 were shown in a previous study to be essential for the activity of the major HAV neutralizing epitope. Swiss-prot ID and positions correspond to the genome polyprotein, not to the mature source protein. 12.5% of acute phase sera recognize this peptide while 2% of normal human sera samples do. The assay experimental conditions were uniformly applied to all synthetic peptides without regard to optimizing assay conditions for each peptide, so authors claim it likely that with proper optimization, the nonspecific immunoreactivity might be significantly reduced or eliminated.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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