Antigenic epitopes of the hepatitis A virus polyprotein. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic epitopes of the hepatitis A virus polyprotein.

Dataset

identifier:	14051
description:	epitope description:QRLKYAQEELSNEVLPPPRK antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10417261

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/941
landingPage:	http://www.iedb.org/assay/14051

Publication

type:	Literature
publicationVenue:	Virology
dates:	1999

Dimension

study type:	b cell assays
subject species:	Human hepatitis A virus Hu/Australia/HM175/1976

Person

fullName:	Y E Khudyakov E N Lopareva D L Jue S Fang J Spelbring K Krawczynski H S Margolis H A Fields

Data Type

method:	ELISA

Study

name:	Antigenic epitopes of the hepatitis A virus polyprotein.
description:	This peptide is part of an immunoreactive domain (aas 767-842 in the viral polyprotein sequence) with high specific reactivity with acute-phase sera samples. The manuscript identifies it as part of P2A protein, while Swiss-prot assigns it to VP1 protein. Swiss-prot ID and positions correspond to the genome polyprotein, not to the mature source protein. 83.3% of acute phase sera recognize this peptide while 1.5% of normal human sera samples do. The assay experimental conditions were uniformly applied to all synthetic peptides without regard to optimizing assay conditions for each peptide, so authors claim it likely that with proper optimization, the nonspecific immunoreactivity might be significantly reduced or eliminated.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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