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Title: Submolecular recognition profiles in two mouse strains of non-protective and protective antibodies against botulinum neurotoxin A.
identifier: 17402
description:
epitope description:ETSEVSTTDKIADITIIIP
antigen name:Botulinum neurotoxin type A (UniProt:A5HZZ9)
host organism:Mus musculus SJL
aggregation:
instance of dataset
availability:
available
primaryPublications: 15950744
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1149
landingPage: http://www.iedb.org/assay/17402
type:
Literature
publicationVenue:
Mol Immunol
dates:
2005
study type: b cell assays
subject species: Clostridium botulinum A
fullName:
M Zouhair Atassi
Gulnoz S Dolimbek
Philip R Deitiker
K Roger Aoki
Behzod Z Dolimbek
method:
radio immuno assay (RIA)
name:
Submolecular recognition profiles in two mouse strains of non-protective and protective antibodies against botulinum neurotoxin A.
description:
Protective sera (day 36 postimmunization) were collected from mice and pooled. IgG was measured by RIA of a 1:250 dilution of the sera. Between days 26 and 36 postimmunization, a switch was observed from non-protective to protective antisera. Protection was mostly associated with the immunoglobulin class of the antibodies. IgM antibodies were non-protective, while IgG antibodies produced after the switch were protective.

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