Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies.

Title:

Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies.

Dataset

identifier:	15387
description:	epitope description:NYNYKYRYLRHGKLRPF antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:4D5
aggregation:	instance of dataset
availability:	available
primaryPublications:	15814718

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1112
landingPage:	http://www.iedb.org/assay/15387

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2005

Dimension

study type:	b cell assays
subject species:	SARS coronavirus

Person

fullName:	Yuxian He Hong Lu Pamela Siddiqui Yusen Zhou Shibo Jiang

Data Type

method:	ELISA

Study

name:	Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies.
description:	17-mer shown to be recognized by one out of 27 mAbs raised against receptor binding domain (RBD) of source protein. Also known as Peplomer protein and E2. 1 out of 27 anti-RBD (receptor binding domain of source protein) mAbs assayed recognize this linear peptide. One other mAb also recognizes an adjacent linear epitope, while 25 recognize conformational epitopes.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.