Peptides mimicking Vibrio cholerae O139 capsular polysaccharide elicit protective antibody response.

Title:

Peptides mimicking Vibrio cholerae O139 capsular polysaccharide elicit protective antibody response.

identifier:	15422
description:	epitope description:AEGEFMGDICSWCYSSAPDPAK host organism:Mus musculus BALB/c antibody name:Vc1
aggregation:	instance of dataset
availability:	available
primaryPublications:	16046165

study type:	b cell assays
subject species:

fullName:	Susanna Falklind-Jerké rus Franco Felici Cristina Cavalieri Carla Lo Passo Gabriella Garufi Ida Pernice Muhammad M Islam Firduasi Qadri Andrej Weintraub

method:	ELISA

name:	Peptides mimicking Vibrio cholerae O139 capsular polysaccharide elicit protective antibody response.
description:	This mimotope mimics a peptide in the Vibrio cholerae O139 capsular polysaccharide. The first five (AEGEF) and last four (DPAK) amino acids belong to the pVIII phage library sequence, which is present in the pC89 vector. The Vibrio cholerae capsular polysaccharide was shown to inhibit binding of the monoclonal antibody to the phage. The reactivity of the monoclonal antibody used for selection and the synthetic peptide conjugate was also verified in an enzyme immunoassay. Survival of suckling Swiss albino mice was assessed 48 hours after being tube fed bacteria preincubated with immune sera from peptide-KLH-immunized mice with 3 out of 12 mice surviving.

name:	iedb
homePage:	http://www.iedb.org

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