Immunological characteristics associated with the protective efficacy of antibodies to ricin. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Immunological characteristics associated with the protective efficacy of antibodies to ricin.

Dataset

identifier:	15453
description:	epitope description:Q208, A213, W246 antigen name:rRNA N-glycosidase (UniProt:B9T8T0) host organism:Mus musculus BALB/c antibody name:mAb 18
aggregation:	instance of dataset
availability:	available
primaryPublications:	15128810

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1113
landingPage:	http://www.iedb.org/assay/15453

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	Ricinus communis

Person

fullName:	Massimo Maddaloni Corrie Cooke Royce Wilkinson Audrey V Stout Leta Eng Seth H Pincus

Data Type

method:	ELISA

Study

name:	Immunological characteristics associated with the protective efficacy of antibodies to ricin.
description:	Phage displayed peptides recognized by a mAb raised against source protein chain A (RAC) share the motif QXXWXXA, which provides a best fit with Q173 A178 W211 on RAC sequence. Swiss-prot ID and positions correspond to the ricin precursor, containing Signal peptide, Chain A, linker peptide and Chain B. The mAb recognizing this sequence is able to bind to RCA and complete holotoxin, both in ELISA and western blot assays. It has a strong relative avidity for the complete toxin.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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