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Title: Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus.
identifier: 16645
description:
epitope description:S592, K593, T616, T618
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
antibody name:E16
aggregation:
instance of dataset
availability:
available
primaryPublications: 15852016
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1173
landingPage: http://www.iedb.org/assay/16645
type:
Literature
publicationVenue:
Nat Med
dates:
2005
study type: b cell assays
subject species: West Nile virus 3000.0259
fullName:
Theodore Oliphant
Michael Engle
Grant E Nybakken
Chris Doane
Syd Johnson
Ling Huang
Sergey Gorlatov
Erin Mehlhop
Anantha Marri
Kyung Min Chung
Gregory D Ebel
Laura D Kramer
Daved H Fremont
Michael S Diamond
method:
surface plasmon resonance (SPR)
name:
Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus.
description:
These residues are located on adjacent loops of Domain III (aa296-415) of source antigen ectodomain, forming a continuous patch on the solvent-exposed surface.
Neutralizing mAb E16, shown to recognize this epitope, recognizes recombinant DIII domain of source protein with a KD of 3.4 nM.

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