Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndrome.

Title:

Dataset

identifier:	17697
description:	epitope description:beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc antigen name:alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')--N-acylsphingosine host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	12183547

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/954
landingPage:	http://www.iedb.org/assay/17697

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2002

Dimension

study type:	b cell assays
subject species:	Vertebrata

Person

fullName:	Tyrone Bowes Eric R Wagner Judith Boffey Dawn Nicholl Lynne Cochrane Mustapha Benboubetra Joe Conner Keiko Furukawa Koichi Furukawa Hugh J Willison

Data Type

method:	ELISA

Study

name:	Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndrome.
description:	The epitope is deduced to be the carbohydrate moiety from the lack of cross-reactivity towards other gangliosides. IgM responses were not significantly cross-reactive between the LPS immunogen and the ganglioside antigen.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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