Synthesis and immunochemical characterization of protein conjugates of carbohydrate and carbohydrate-mimetic peptides as experimental vaccines.

Title:

Synthesis and immunochemical characterization of protein conjugates of carbohydrate and carbohydrate-mimetic peptides as experimental vaccines.

identifier:	18244
description:	epitope description:S. flexneri Y polysaccharide antigen name:lipopolysaccharide host organism:Mus musculus antibody name:SYA/J6
aggregation:	instance of dataset
availability:	available
primaryPublications:	15186860

study type:	b cell assays
subject species:	Shigella flexneri Y

fullName:	Rehana B Hossany Margaret A Johnson Adewale A Eniade B Mario Pinto

method:	antigen inhibition

name:	Synthesis and immunochemical characterization of protein conjugates of carbohydrate and carbohydrate-mimetic peptides as experimental vaccines.
description:	The epitope is part of the repeat unit of the O-PS from S.flexneri Y LPS. The unconjugated 10 repetitive units of the epitope (not just one as depicted here) is able to inhibit binding of SYA/J6 mAb to Y. flexneri LPS, with similar IC50 than sacccaharide-linker(squarate)-TT conjugate, with a conjugation ratio of 44 epitope-linker molecules per TT molecule,

name:	iedb
homePage:	http://www.iedb.org

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