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identifier: 19510
description:
epitope description:G138, R146
antigen name:Hemagglutinin
host organism:Mus musculus
antibody name:5H4 and 8B3
aggregation:
instance of dataset
availability:
available
primaryPublications: 11745940
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1302
landingPage: http://www.iedb.org/assay/19510
type:
Literature
publicationVenue:
J Med Virol
dates:
2001
study type: b cell assays
subject species: Influenza B virus (B/Kadoma/122/99)
fullName:
N Nakagawa
R Kubota
S Morikawa
T Nakagawa
K Baba
Y Okuno
method:
biological activity
name:
Characterization of new epidemic strains of influenza B virus by using neutralizing monoclonal antibodies.
description:
Two laboratory induced antigenic variants of influenza B virus B/Kadoma/122/99 produced negative responses to the monoclonal antibodies in PAP staining, hemagglutination-inhibition, and neutralization tests. The variants were found to have single amino acid substitutions at position 141 (Gly to Arg) or position 149 (Arg to Gly). Several natural epidemic variants were also shown to contain the mutation at position 149.

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