Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1264 |
| landingPage: |
http://www.iedb.org/assay/20335 |
| type: |
Literature
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| publicationVenue: |
Vaccine
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| dates: |
2003
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| study type: | b cell assays |
| subject species: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
| fullName: |
Krystyna Mozdzanowska
JinQi Feng
Mark Eid
Goran Kragol
Mare Cudic
Laszlo Otvos Jr
Walter Gerhard
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| method: |
ELISA
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| name: |
Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2.
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| description: |
S residues were substituted for the natural C residues at positions 16 and 18 to prevent disulfide bonding. The paper uses the A/PR/8/34/Mount Sinai strain, but the sequence of the M2e peptide is not found in this strain. The Swiss Prot ID given is for Influenza A virus (A/USSR/90/77(H1N1). Several flu strains contain this sequence.
The authors specify that mAb 14C2 is specific to this epitope. Multi-epitope constructs consisting of 1 copy of M2e (a matrix protein 2 ectodomain epitope from influenza A virus), 1 copy each of S1 and S2 (hemagglutinin peptides) were used as antigens.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
