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Title: Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1.
identifier: 20337
description:
epitope description:ELDLQARR
antigen name:Enterotoxin type A
host organism:Mus musculus BALB/c
antibody name:MAb5
aggregation:
instance of dataset
availability:
available
primaryPublications: 11372026
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1314
landingPage: http://www.iedb.org/assay/20337
type:
Literature
publicationVenue:
J Infect Dis
dates:
2001
study type: b cell assays
subject species: Staphylococcus aureus
fullName:
W W Kum
A W Chow
method:
biological activity
name:
Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1.
description:
The monoclonal antibody (MAb5) is a known anti-toxic shock syndrome toxin-1 antibody. MAb5 significantly inhibited 125I-labeled staphylococcal enterotoxin A binding to human monocytes in a dose-dependentmanner. MAb5 also inhibited staphylococcal enterotoxin A-induced T cell mitogenesis in human PBMC in a dose-dependent manner, and was further shown to inhibit staphylococcal enterotoxin A-induced TNF-alpha, IL-1beta, and IL-6 production from human PBMC.

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