Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins.

Title:

Dataset

identifier:	22146
description:	epitope description:GRLITVNPIVT antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:4G2, 2C5.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	10664386

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1419
landingPage:	http://www.iedb.org/assay/22146

Publication

type:	Literature
publicationVenue:	Arch Virol
dates:	1999

Dimension

study type:	b cell assays
subject species:	Dengue virus 2

Person

fullName:	A K Falconar

Data Type

method:	ELISA

Study

name:	Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins.
description:	The epitope specificity of these monoclonal antibodies was identified by scan of overlapping peptides spanning amino acids 301-401 of the E protein. In this assay, the monoclonal antibodies exhibited a stronger reactivity with the corresponding peptide sequence from the attenuated dengue 2 virus strain which contains an amino acid substitution at the fourth residue.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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