Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins.

Title:

Dataset

identifier:	22163
description:	epitope description:PGFTVMAAIL antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:2A4.1, 2H2
aggregation:	instance of dataset
availability:	available
primaryPublications:	10664386

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1419
landingPage:	http://www.iedb.org/assay/22163

Publication

type:	Literature
publicationVenue:	Arch Virol
dates:	1999

Dimension

study type:	b cell assays
subject species:	Dengue virus 2

Person

fullName:	A K Falconar

Data Type

method:	western blot

Study

name:	Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins.
description:	This peptide is said to be located at positions 40-49 within the first membrane-spanning domain of the M protein of Dengue virus 2. Sequence of this protein found in current databases do not harbor this sequence but PGFTIMAAIL. An internal database source is provided here to account for the discrepancy between the reported sequence and that found in current genebank/swiss-prot databases. Similar reactivities were shown against proteins from dengue virus types 1, 2, 3, and 4.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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