Mucosal T cells induce systemic anergy for oral tolerance. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Mucosal T cells induce systemic anergy for oral tolerance.

Dataset

identifier:	1046784
description:	epitope description:SYTESMAGKREMVIITIKSG antigen name:Other Escherichia coli protein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	7818546

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000561
landingPage:	http://www.iedb.org/assay/1046784

Publication

type:	Literature
publicationVenue:	Biochem Biophys Res Commun
dates:	1995

Dimension

study type:	b cell assays
subject species:	Escherichia coli

Person

fullName:	I Takahashi I Nakagawa H Kiyono J R McGhee J D Clements S Hamada

Data Type

method:	ELISA

Study

name:	Mucosal T cells induce systemic anergy for oral tolerance.
description:	Intravenous and oral (2X weekly) immunizations with the epitope induced epitope-specific serum IgG responses. However, when the mice were fed the epitope (peptide) four times weekly, the serum IgG responses were suppressed (oral tolerization). Mice fed the epitope (peptide) developed enhanced fecal IgA responses specific for the epitope which remained even after four consecutive feedings (data not shown). These results indicate systemic unresponsiveness to the antigen with multiple feedings but the mucosal response remains unaltered.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.