Distinct glycoprotein inhibitors of influenza A virus in different animal sera. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Distinct glycoprotein inhibitors of influenza A virus in different animal sera.

Dataset

identifier:	1003524
description:	epitope description:R220 antigen name:Hemagglutinin host organism:Mus musculus antibody name:M12/3, M2/1, M2/4, M2/5, B45/5
aggregation:	instance of dataset
availability:	available
primaryPublications:	1702161

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000089
landingPage:	http://www.iedb.org/assay/1003524

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1991

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Los Angeles/1987(H3N2))

Person

fullName:	K A Ryan-Poirier Y Kawaoka

Data Type

method:	biological activity

Study

name:	Distinct glycoprotein inhibitors of influenza A virus in different animal sera.
description:	The key residue was identified based on sequence analysis of viral variants that did not react with anti-H3 HA monoclonal antibodies in hemagglutination-inhibition assays. Variants of the parent influenza A virus, A/Los Angeles/2/87(H3N2), were selected based on serum-inhibition resistance to normal horse, pig, and rabbit sera (which contain inhibitors of infectivity and hemagglutinating activity of influenza A viruses of H2 and H3 subtypes) and were examined at the molecular level for changes in the HA molecule aquired during the development of serum inhibitor resistance.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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