Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.

Title:

Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.

identifier:	1003749
description:	epitope description:D79 antigen name:Hemagglutinin host organism:Mus musculus CBA/Ca antibody name:HA1 63
aggregation:	instance of dataset
availability:	available
primaryPublications:	8163950

study type:	b cell assays
subject species:	Influenza A virus (A/X-31(H3N2))

fullName:	F D B Thomas

method:	biological activity

name:	Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.
description:	This key residue was identified by sequence analysis of viral escape mutants selected by a monoclonal antibody. The protein sequence cited includes a 16 amino acid precursor. The monoclonal antibody was used to select an escape mutant of the X31 virus (a recombinant between A/Aichi/2/68 and A/PR/8/34). The specificity of the monoclonal antibody was previously determined.

name:	iedb
homePage:	http://www.iedb.org

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