Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.

Title:

Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.

identifier:	1003754
description:	epitope description:V212 antigen name:Hemagglutinin host organism:Mus musculus CBA/Ca antibody name:FO1-11, FO1-32
aggregation:	instance of dataset
availability:	available
primaryPublications:	8163950

study type:	b cell assays
subject species:	Influenza A virus (A/X-31(H3N2))

fullName:	F D B Thomas

method:	biological activity

name:	Modulation of immunodominant sites in influenza hemagglutinin compromise antigenic variation and select receptor-binding variant viruses.
description:	This key residue was identified by sequence analysis of viral escape mutants selected by a monoclonal antibody. The Influenza A virus (X-31(H3N2)) was a novel variant virus with mutations at specific amino acids (HA1 63, 144, 158, and 193) in regions previously shown to be immunodominant for CBA/Ca mice. The protein sequence cited contains a 16 amino acid precursor. The monoclonal antibody was used to select an escape mutant of the X31 virus (a recombinant between A/Aichi/2/68 and A/PR/8/34).

name:	iedb
homePage:	http://www.iedb.org

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