A hemagglutinin-based multipeptide construct elicits enhanced protective immune response in mice against influenza A virus infection.

Title:

A hemagglutinin-based multipeptide construct elicits enhanced protective immune response in mice against influenza A virus infection.

identifier:	1004816
description:	epitope description:VTGLRNIPSIQSR antigen name:Hemagglutinin host organism:Mus musculus BALB/c antibody name:Pooled sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	9557954

study type:	b cell assays
subject species:	Influenza A virus (A/Puerto Rico/8/1934(H1N1))

fullName:	A Horvá th G K Tó P Gogolá k Z Nagy I Kurucz I Pecht E Rajnavö lgyi

method:	ELISA

name:	A hemagglutinin-based multipeptide construct elicits enhanced protective immune response in mice against influenza A virus infection.
description:	The HA0 317-341 epitope analog, HA1 317-329 peptide was tested in three forms: monovalent HA1 317-329, polyvalent (HA1 317-329)₄ and polyvalent (HA1 317-329)₄ with fusion partner FP3 (HA2 1-12). Epitope HA1 317-329 from the hemagglutinin protein of Influenza A virus strain PR8 was previously characterized by Lamb JK et al. Nature 1982 300:66-69. This peptide was derived from the longer HA0 317-341 antigenic region. The reactivity of (HA1 317-329)₄ with fusion partner FP3 (HA2 1-12) - induced polycloncal antibody with different forms of Influenza A virus hemagglutinin (HA) was measured. High titers were observed against HA preteated with acid (pH 5) and HA from chicken embryonic cells. IgG1 was found to be the predominant isotype involved. Monoclonal antibodies generated against ths peptide were also able to react with the peptide itself as well as different forms of Influenza A virus hemagglutinin (Table 2).

name:	iedb
homePage:	http://www.iedb.org

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