Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus.

Dataset

identifier:	1004747
description:	epitope description:T226, V266 antigen name:Hemagglutinin-esterase-fusion glycoprotein host organism:Mus musculus antibody name:D37
aggregation:	instance of dataset
availability:	available
primaryPublications:	1376542

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000236
landingPage:	http://www.iedb.org/assay/1004747

Publication

type:	Literature
publicationVenue:	Virology
dates:	1992

Dimension

study type:	b cell assays
subject species:	Influenza C virus (C/Ann Arbor/1/50)

Person

fullName:	M Matsuzaki K Sugawara K Adachi S Hongo H Nishimura F Kitame K Nakamura

Data Type

method:	biological activity

Study

name:	Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus.
description:	This key residues from antigenic site 4 were identified by sequence analysis of viral escape mutants. The amino acid positions provided in the manuscript do not correspond to the sequence provided in the SwissProt entry cited. Viral escape mutants of the parent virus were selected for their resistance to neutralization by the monoclonal antibody, and their hemagglutinin-esterase glycoprotein genes were subsequently sequenced. Three distinct variants were selected. Amino acid changes at residue 266 were shown to increase hemagglutinating activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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