Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities.

Title:

Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities.

identifier:	1005226
description:	epitope description:L226 antigen name:Hemagglutinin host organism:Mus musculus antibody name:HC68, HC67, Mem 3, HC3M, Mem 25.
aggregation:	instance of dataset
availability:	available
primaryPublications:	6208680

study type:	b cell assays
subject species:	Influenza A virus (A/X-31(H3N2))

fullName:	R S Daniels A R Douglas J J Skehel D C Wiley C W Naeve R G Webster G N Rogers J C Paulson

method:	biological activity

name:	Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities.
description:	This key residue was previously identified as a key residue distinguishing viruses that recognize receptor sialic acid in the alpha2-3 linkage from viruses recognizing alpha2-6 linkages. In the present study, monoclonal antibodies with previously defined key residue specificities, determined by escape mutant analysis, were shown to discriminate between these two viruses in hemagglutination-inhibition assays. They key residue specificities of the monoclonal antibodies is as follows: HC68: S193, HC67: S193, Mem 3: S199, HC3M: S219, Mem 25: R229.

name:	iedb
homePage:	http://www.iedb.org

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