Prevention of infection of influenza virus in DQ6 mice, a human model, by a peptide vaccine prepared according to the cassette theory.

Title:

Prevention of infection of influenza virus in DQ6 mice, a human model, by a peptide vaccine prepared according to the cassette theory.

identifier:	1006839
description:	epitope description:WTGVTQN antigen name:Hemagglutinin host organism:Mus musculus HLA-DQ6 Tg
aggregation:	instance of dataset
availability:	available
primaryPublications:	10195628

study type:	b cell assays
subject species:	Influenza A virus (A/Aichi/2/1968(H3N2))

fullName:	N Matsuki K Ogasawara K K Namba A Takahashi Y Fukui T Sasazuki K Iwabuchi R A Good K Onoé

method:	ELISA

name:	Prevention of infection of influenza virus in DQ6 mice, a human model, by a peptide vaccine prepared according to the cassette theory.
description:	Transgenic DQ6 mice were immunized with the H3-H3 peptide (YEGFSWTGVTQNKAKGITWTGVTQN) or the 46F/HA127-133/54A peptide (YEGFSWTGVTQNKAKGIT), which both contain the HA127-133 epitope within a known MHC binding sequence from an analog of pigeon cyochrome c (PCC) 43-58. Serum antibody titers were measured against the HA 123-128 peptide, the 46F/HA127-133/54A peptide, or control peptides that contained the MHC binding sequence from PCC, but not the HA 127-133 epitope sequence. Immunization with either H3-H3 or 46F/HA127-133/54A led to detectable antibody titers to HA 123-138 and 46F/HA127-133/54A, but not to the control peptides. Thus, immunization with peptides induced an antibody response to the HA127-133 epitope, but not to the MHC binding sequence within the immunizing peptide. Higher titers were observed in H3-H3 immunized mice than in 46F/HA127-133/54A immunized mice.

name:	iedb
homePage:	http://www.iedb.org

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