Chemical chaperones enhance superantigen and conventional antigen presentation by HLA-DM-deficient as well as HLA-DM-sufficient antigen-presenting cells and enhance IgG2a production in vivo.

Title:

Chemical chaperones enhance superantigen and conventional antigen presentation by HLA-DM-deficient as well as HLA-DM-sufficient antigen-presenting cells and enhance IgG2a production in vivo.

Dataset

identifier:	1032229
description:	epitope description:2,4,6-trinitrophenyl group host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	9759841

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000468
landingPage:	http://www.iedb.org/assay/1032229

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1998

Dimension

study type:	b cell assays
subject species:

Person

fullName:	B Ghumman E M Bertram T H Watts

Data Type

method:	ELISA

Study

name:	Chemical chaperones enhance superantigen and conventional antigen presentation by HLA-DM-deficient as well as HLA-DM-sufficient antigen-presenting cells and enhance IgG2a production in vivo.
description:	This study was performed to asses the adjuvant effect of glycerol on the response against TNP, by comparing to the injection in PBS and bound to alum. It was seen that even when there was no enhancement of the primary response by glycerol at 2 different concentrations, the secondary reponse was enhanced over alum for the IgG2a isotype, while similar than alum for IgG1. Thus, although the adjuvant effect of glycerol in vivo is relatively weak, it may serve for favoring Th1 responses.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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