Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes.

Dataset

identifier:	1032546
description:	epitope description:D155, T158 antigen name:Genome polyprotein host organism:Mus musculus antibody name:B39
aggregation:	instance of dataset
availability:	available
primaryPublications:	9191929

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000519
landingPage:	http://www.iedb.org/assay/1032546

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Yellow fever virus 17D/Tiantan

Person

fullName:	K D Ryman T N Ledger R C Weir J J Schlesinger A D Barrett

Data Type

method:	biological activity

Study

name:	Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes.
description:	These residues on the envelope protein of yellow fever virus (strain: 17D-204-WHO) are critical for binding to the monoclonal antibody B39 mutations at these sites cause neutralization escape variants. The monoclonal antibody B39 neutralizes yellow fever virus 17D-204-WHO but not the variants B39^RWHO-1 and B39^RWHO-2; these indicate that mutations occur in the epitope in the parental strain (17D-204-WHO) that causes loss of binding by the antibody to the variant/resistant strains. Nucleotide sequencing of the E proteins of the different variants shows where the mutations occurred.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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