Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies.

Title:

Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies.

Dataset

identifier:	1212889
description:	epitope description:TTLNPTIA antigen name:Major outer membrane porin, serovar D host organism:Mus musculus antibody name:E4, L1-4, L1-24
aggregation:	instance of dataset
availability:	available
primaryPublications:	1718870

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000624
landingPage:	http://www.iedb.org/assay/1212889

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	1991

Dimension

study type:	b cell assays
subject species:	Chlamydia trachomatis

Person

fullName:	E M Peterson X Cheng B A Markoff T J Fielder L M de la Maza

Data Type

method:	western blot

Study

name:	Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies.
description:	The sequence in Swissprot is 393 AA in length, with the first 22 AA representing the signal sequence. All 15 serovars of C. trachomatis tested positive.Mabs E4, L1-4 and L1-24 recognized all 15 serovars. Although the epitope is localized to a linear sequence, there may be some conformational element to the true epitope especially for antibodies L1-4 and L1-24.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.