Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1000670 |
| landingPage: |
http://www.iedb.org/assay/1212757 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
1985
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| study type: | b cell assays |
| subject species: | Escherichia coli |
| fullName: |
R A Houghten
R F Engert
J M Ostresh
S R Hoffman
F A Klipstein
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| method: |
ELISA
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| name: |
A completely synthetic toxoid vaccine containing Escherichia coli heat-stable toxin and antigenic determinants of the heat-labile toxin B subunit.
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| description: |
The immunogenicity of this peptide in monomeric form was evaluted by immunizing rats with this material given either alone or conjugated to a high-molecular-weight carrier, porcine IgG. The conjugated peptide raised titers of intestinal IgA antitoxin to heat-stable toxin and provided protection against challenge with the viable LT+/ST- strain. The peptide was also shown to be non-toxic. Twice the dose was necessary to achieve this level of protection in mice immunized by the peroral route only.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
