Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus.

Title:

Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus.

identifier:	1242952
description:	epitope description:LTEVETPIRNEWG antigen name:Matrix protein 2 host organism:Mus musculus BALB/c antibody name:14C2
aggregation:	instance of dataset
availability:	available
primaryPublications:	16472860

study type:	b cell assays
subject species:	Influenza A virus (A/Puerto Rico/8/1934(H1N1))

fullName:	Manxin Zhang Darya Zharikova Krystyna Mozdzanowska Laszlo Otvos Walter Gerhard

method:	antigen inhibition

name:	Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus.
description:	This peptide represents an N and C terminal truncation of the full length M2e 2-25 peptide [SLLTEVETPIRNEWGCRCNGSSD] of influenza A virus (PR8). The specificity of a panel of mAbs to truncated M2e peptides was tested by IC50 in ELISA format. Peptide M2e 4-16, with both N and C terminal truncations, bound as well as or out-competed the longer M2e 2-25 for binding to the mAbs. The M2e 4-16 peptide bound well to mAb 14C2, and this response was significantly higher than that of full-length M2e 2-25.

name:	iedb
homePage:	http://www.iedb.org

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