Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1000566 |
| landingPage: |
http://www.iedb.org/assay/1068851 |
| type: |
Literature
|
| publicationVenue: |
Vaccine
|
| dates: |
1995
|
| study type: | b cell assays |
| subject species: | Venezuelan equine encephalitis virus (strain Trinidad donkey) |
| fullName: |
A R Hunt
J T Roehrig
|
| method: |
antigen inhibition
|
| name: |
Localization of a protective epitope on a Venezuelan equine encephalomyelitis (VEE) virus peptide that protects mice from both epizootic and enzootic VEE virus challenge and is immunogenic in horses.
|
| description: |
This peptide was derived from the 25 amino acid VEE E2 glycoprotein peptide, pep01(STEELFKEYKLTRPYMARCIRCAVG), which was previously defined and described by Hunt AR. et al. Virol 1990
179:701-711.
In order to further characterize the p1-19 epitope, a panel of 12 overlapping octamers of p1-19 was generated. A competitive binding assay was then performed using mAb 1A2B-10 to assess whether these octamers could inhibit its binding to plate-bound p1-19 or virus (VEE TRD). MAb 1A2B-10 was capable of recognizing p3-10, and to a lessr extent, p2-9.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
