Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1000815 |
| landingPage: |
http://www.iedb.org/assay/1079912 |
| type: |
Literature
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| publicationVenue: |
Mol Microbiol
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| dates: |
1996
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| study type: | b cell assays |
| subject species: | Human alphaherpesvirus 1 |
| fullName: |
J A Chabalgoity
C M Khan
A A Nash
C E Hormaeche
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| method: |
in vivo assay
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| name: |
A Salmonella typhimurium htrA live vaccine expressing multiple copies of a peptide comprising amino acids 8-23 of herpes simplex virus glycoprotein D as a genetic fusion to tetanus toxin fragment C protects mice from herpes simplex virus infection.
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| description: |
The author identified positions reflect that of th mature protein
here the source is the precursor.
Virus load in ears of HSV-1 (strain SC16)-challenged mice were reduced if they received prior immunizations with S. typhimurium live vaccines transfected with a plasmid that encodes multiple copies of a peptide containing the epitope (HSV-1 gD peptide 8-23:SLKMADPNRFRGKDLP). Serum antibody titres from these mice correlated well with the viral load reduction.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
